Our liver is attacked every day by various pathogens which can vary from being various microorganisms (bacteria, viruses) to being different harmful chemical substances. In fact, we are threatened by more factors than we can even imagine; some of the most dangerous are:
- Junk food
- Various drugs (especially antibiotics and non steroidal anti-inflammatory drugs)
- Viruses (Hepatitis A, B or C viruses for example)
And these are only some of the pathogens that can lead you into acquiring unpleasant illnesses and states like hepatitis, cirrhosis (alcoholic or viral), cholecystitis, hepatosis, fatty liver and so on. Liver diseases are very difficult to manage and most of them are incurable.
Despite the fact that liver has a lot of protective mechanisms (complex immune mechanisms) that keep it in good shape (note: liver must always be in good shape as it is of crucial importance to the organism and scientists believe it manages over 500 various functions that are important for the organism) bad ecology, bad food and bad habits are things that can surpass the livers protective mechanism and lead to irreversible liver damage.
How can Kratom protect your liver?
The effects of Kratom alkaloid extract (MSE) on human recombinant cytochrome P450 (CYP) enzyme activities have been studied to show significant liver protective effects.
The results indicated that MSE has the most potent inhibitory effect on CYP3A4 and CYP2D6 (which may have harmful effects on liver tissue) which showed that M. speciosa alkaloid extract may contribute to an herb-drug interaction if administered concomitantly with drugs that are substrates for CYP3A4, CYP2D6 and CYP1A2, and others. Along with this experiments have been conducted on mice that showed a protective role against carbon tetrachloride (CCl4)-induced acute liver injury. These are indeed significant results that prove the potent hepatoprotective features of Kratom.
What strains are the best and in what doses?
The most potent and richest in alkaloids that offer hepatoprotective features are Red strain and green strain:
To achieve a hepatoprotective effect you must not take more or less than your regular kratom dosage (mostly between 5-15gr). Experienced users may take the dose which they are comfortable with. Newbies must begin with 5gr and be careful with high doses. As hepatoprotective is not a main effect of Kratom (like anti0inflamatory or immune-stimulating for example) the dose does not play so crucial a role, as long as it is not very low or high (very high doses can be toxic for your liver as well, due to high concentrations of alkaloids in blood that passes through the liver).
Strength and conditions
It is difficult to tell about the strength or potency of a certain species when it comes to liver protection. This is because certain strains have not been studied in detail considering this function; just a general analysis.
So whatever you take is good, as long as it’s potent and the doses (as mentioned earlier) are not too high or low. When speaking about conditions there is nothing more or less to say that: it is primarily protecting the liver from harmful agents, so you won’t really feel it or be able to tell the strength of the effect, that’s one thing; the other thing that must be said is: as its effect is primarily protective and preventive, keep in mind that if you acquire a liver disease Kratom will not be able to help you effectively anymore and you MUST visit a doctor.